Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy

Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy

Abstract Background Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in CRPC cells and its potential mechanisms. Methods The effect of MSCs on...

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Bibliographic Details
Main Authors: Yang Yu, Fu-han Yang, Wen-tao Zhang, Ya-dong Guo, Lin Ye, Xu-dong Yao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cell & Bioscience
Subjects:
Mesenchymal stem cells
Prostate cancer
Docetaxel resistance
Autophagy
Transforming growth factor-β1
Online Access:https://doi.org/10.1186/s13578-020-00494-0

Internet

https://doi.org/10.1186/s13578-020-00494-0

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