PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation

Abstract A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 is...

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Bibliographic Details
Main Authors: Tong Li, Jinbo Han, Liangjie Jia, Xiao Hu, Liqun Chen, Yiguo Wang
Format: Article
Language:English
Published: SpringerOpen 2019-03-01
Series:Protein & Cell
Subjects:
PKM2
MFN2
mTOR
glycolysis
oxidative phosphorylation
Online Access:http://link.springer.com/article/10.1007/s13238-019-0618-z

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http://link.springer.com/article/10.1007/s13238-019-0618-z

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