Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA

Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA

Axon regeneration in the adult central nervous system (CNS) is prevented by inhibitory molecules present in myelin, which bind to a receptor complex that leads to downstream RhoGTP activation and axon growth cone collapse. Here, we compared expression of Citron kinase (Citron-K), a target molecule o...

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Bibliographic Details
Main Authors: Zubair Ahmed, Michael R. Douglas, Martin L. Read, Martin Berry, Ann Logan
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Citron-K
Dorsal root ganglion neurons
CNS
Axon regeneration
siRNA
Neurite outgrowth
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003463

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110003463

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