Nrf2 in cancers: A double‐edged sword

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage induced by exogenous chemicals. It maintains the redox homeostasis, exerts anti‐inflammation and anticancer activity by regulating its multiple downstream cytoprotective genes, thereb...

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Bibliographic Details
Main Authors: Shijia Wu, Hong Lu, Yongheng Bai
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.2101