Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

Abstract Background Traumatic brain injury (TBI) is a critical public health and socioeconomic problem throughout the world. Inflammation-induced secondary injury is one of the vital pathogenic parameters of TBI. Molecular signaling cascades of pyroptosis, a specific type of cellular necrosis, are k...

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Bibliographic Details
Main Authors: Wei Liu, Yuhua Chen, Jiao Meng, Minfei Wu, Fangfang Bi, Cuicui Chang, Hua Li, Liangjun Zhang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
TBI
Inflammation
Neuroinflammation
Pyroptosis
Caspase-1
Neuron damage
Online Access:http://link.springer.com/article/10.1186/s12974-018-1083-y

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http://link.springer.com/article/10.1186/s12974-018-1083-y

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