Quantitative analysis of binary mixtures of entecavir using solid-state analytical techniques with chemometric methods

Quantitative analysis of binary mixtures of entecavir using solid-state analytical techniques with chemometric methods

Entecavir (ETV), a guanosine analogue, can be rapidly phosphorylated to the active intracellular triphosphate form that inhibits replication of the hepatitis B virus (HBV). This work aims to develop useful methods to quantify the content of ETV-A in ETV-H and ETV-A binary mixtures. The integral enth...

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Bibliographic Details
Main Authors: Mingdi Liu, Peng Shi, Guangle Wang, Gang Wang, Ping Song, Yumin Liu, Songgu Wu, Junbo Gong
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Arabian Journal of Chemistry
Subjects:
Entecavir
Anhydride impurity
Quantification
DSC
PXRD
ATR-FTIR
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221003750

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http://www.sciencedirect.com/science/article/pii/S1878535221003750

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