Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors

Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular target for clinical and agricultural antifungals. SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has been focused on using SDM inhibitors to tr...

Full description

Bibliographic Details
Main Author: David J. Leaver
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
sterol biosynthesis
sterol 14α-demethylase
sterol C24-methyltransferase
mechanism-based inactivators
antifungals
azoles
antiparasitic drugs
human African trypanosomiasis
Chagas disease
synthesis
Online Access:http://www.mdpi.com/1420-3049/23/7/1753

Internet

http://www.mdpi.com/1420-3049/23/7/1753

Similar Items