T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

Abstract Background Traditional therapies fail to cure most glioblastoma patients and the 5-year survival rate is less than 10%, highlighting need for new therapeutic approaches. The natural killer group 2 member D ligands (NKG2DLs) are highly expressed in glioblastomas and are considered promising...

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Bibliographic Details
Main Authors: Dong Yang, Bin Sun, Hongjiu Dai, Wenxuan Li, Lan Shi, Peixian Zhang, Shirong Li, Xudong Zhao
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Chimeric antigen receptor
Glioblastoma
Cancer stem cell
NKG2D
Online Access:http://link.springer.com/article/10.1186/s40425-019-0642-9

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http://link.springer.com/article/10.1186/s40425-019-0642-9

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