Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.

Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.

The hypomethylating agent 5-Azacytidine (5-Aza-CR) is the first drug to prolong overall survival in patients with myelodysplastic syndrome (MDS). Surprisingly, the deoxyribonucleoside analog 5-Aza-2'deoxycytidine (5-Aza-CdR) did not have a similar effect on survival in a large clinical trial. B...

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Bibliographic Details
Main Authors: Xiangning Qiu, Christoffer Hother, Ulrik M Ralfkiær, Alexandra Søgaard, Qianjin Lu, Christopher T Workman, Gangning Liang, Peter A Jones, Kirsten Grønbæk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2947512?pdf=render

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http://europepmc.org/articles/PMC2947512?pdf=render

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