AXL receptor tyrosine kinase: a possible therapeutic target in acute promyelocytic leukemia

AXL receptor tyrosine kinase: a possible therapeutic target in acute promyelocytic leukemia

Abstract Background Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. All-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) have resulted in dur...

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Bibliographic Details
Main Authors: Mariam Fatima, Salik Javed Kakar, Fazal Adnan, Khalid Khan, Afsar Ali Mian, Dilawar Khan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Cancer
Subjects:
Acute promyelocytic leukemia
Retinoic acid receptor-α
PML/RARα
All-trans retinoic acid
Wnt/β-catenin pathway
AXL
Online Access:https://doi.org/10.1186/s12885-021-08450-y

Internet

https://doi.org/10.1186/s12885-021-08450-y

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