The effect of the disulfideisomerase domain containing protein in the defense against polyhexamethylene biguanide of highly tolerant Acanthamoeba at the trophozoite stage

Acanthamoeba castellanii is a free-living protozoan pathogen capable of causing a blinding keratitis and fatal granulomatous encephalitis. Current treatment generally involves an hourly application of polyhexamethylene biguanide (PHMB) over a period of several days but this is not entirely effective...

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Bibliographic Details
Main Authors: Fu-Chin Huang, Tao-Shen Liu, Sung-Chou Li, Min-Hsiu Shih, Jyh-Wei Shin, Wei-Chen Lin
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300768