Heat Shock Protein Inhibitor 17-Allyamino-17-DemethoxygelDanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters

Heat Shock Protein Inhibitor 17-Allyamino-17-DemethoxygelDanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and has a poor prognosis. Complex genetic alterations and the protective effect of the blood–brain barrier (BBB) have so far hampered effective treatment. Here, we investigated the cytotoxic effects of heat shock protein...

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Bibliographic Details
Main Authors: Nikola Pastvova, Petr Dolezel, Petr Mlejnek
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
tanespimycin
human glioma tumor cell panel
apoptosis
blood brain barrier
multidrug resistance
ABC transporters
Online Access:https://www.mdpi.com/1424-8247/14/2/107

Internet

https://www.mdpi.com/1424-8247/14/2/107

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