Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death[S]

Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death[S]

The 24(S)-hydroxycholesterol (24S-OHC), which plays an important role in maintaining brain cholesterol homeostasis, has been shown to possess neurotoxicity. We have previously reported that 24S-OHC esterification by ACAT1 and the resulting lipid droplet (LD) formation are responsible for 24S-OHC-ind...

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Bibliographic Details
Main Authors: Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Journal of Lipid Research
Subjects:
acyl-CoA:cholesterol acyltransferase
Alzheimer's disease
electron microscopy
mass spectrometry
oxysterols
24(S)-hydroxycholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345727

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http://www.sciencedirect.com/science/article/pii/S0022227520345727

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