The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells

The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells

Summary: Brain metastasis is an ineffective process, and many cancer cells enter into an indolent state following extravasation in the brain. Single cell RNA sequencing of melanoma brain metastases reveals that non-proliferating brain metastatic melanoma cells exhibit a pattern of gene expression as...

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Bibliographic Details
Main Authors: Eishu Hirata, Kojiro Ishibashi, Shinji Kohsaka, Keiko Shinjo, Shinya Kojima, Yutaka Kondo, Hiroyuki Mano, Seiji Yano, Etsuko Kiyokawa, Erik Sahai
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Biological Sciences
Cell Biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306726

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220306726

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