Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation

Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation

Abstract Lychnopholide, a lipophilic sesquiterpene lactone, is efficacious in mice at the acute and chronic phases of Chagas disease. Conventional poly-ε-caprolactone (PCL) and long-circulating poly(D,L-lactide)-block-polyethylene glycol (PLA-PEG) nanocapsules containing lychnopholide were developed...

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Bibliographic Details
Main Authors: Renata Tupinambá Branquinho, Gwenaelle Pound-Lana, Matheus Marques Milagre, Dênia Antunes Saúde-Guimarães, José Mário Carneiro Vilela, Margareth Spangler Andrade, Marta de Lana, Vanessa Carla Furtado Mosqueira
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08469-x

Internet

https://doi.org/10.1038/s41598-017-08469-x

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