Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals Induce Long-Lasting Non-Opioid Peripheral Analgesia in a Rat Model of Inflammatory Pain

Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals Induce Long-Lasting Non-Opioid Peripheral Analgesia in a Rat Model of Inflammatory Pain

The negative side effects of opioid-based narcotics underscore the search for alternative non-opioid bioactive compounds that act on the peripheral nervous system to avoid central nervous system-mediated side effects. The transient receptor potential V1 ion channel (TRPV1) is a peripheral pain gener...

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Bibliographic Details
Main Authors: Paramita Basu, Sirima A. Tongkhuya, Taylor L. Harris, Angela R. Riley, Camelia Maier, John Granger, Jennie Wojtaszek, Dayna L. Averitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
analgesia
diterpenes
Euphorbia
flavonoids
hyperalgesia
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00958/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00958/full

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