Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus

Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus

We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity are unknown. Here, using a pristane-induced model, we show that tRA exerts differential effects when...

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Bibliographic Details
Main Authors: Leila Abdelhamid, Xavier Cabana-Puig, Brianna Swartwout, Jiyoung Lee, Song Li, Sha Sun, Yaqi Li, A. Catharine Ross, Thomas E. Cecere, Tanya LeRoith, Stephen R. Werre, Haifeng Wang, Christopher M. Reilly, Xin M. Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
retinoic acid
pristane-induced
lupus
stage-dependent
kidney
glomerulonephritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00408/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00408/full

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