Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients

Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients

Background: Visceral leishmaniasis/HIV-co-infected patients (VL/HIV) accounts for around 8% of VL reported cases in Brazil. Relapses of Leishmania infection after anti-leishmanial treatment constitute a great challenge in the clinical practice because of the disease severity and drug resistance. We...

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Bibliographic Details
Main Authors: Maria Luciana Silva-Freitas, Gabriela Corrêa-Castro, Glaucia Fernandes Cota, Carmem Giacoia-Gripp, Ana Rabello, Juliana Teixeira Dutra, Zilton Farias Meira de Vasconcelos, Wilson Savino, Alda Maria Da-Cruz, Joanna Reis Santos-Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis/HIV-1 co-infection
thymic output
TCRVβ repertoire
relapses
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00953/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00953/full

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