Pathway-specific protein domains are predictive for human diseases.

Protein domains are basic functional units of proteins. Many protein domains are pervasive among diverse biological processes, yet some are associated with specific pathways. Human complex diseases are generally viewed as pathway-level disorders. Therefore, we hypothesized that pathway-specific doma...

Full description

Bibliographic Details
Main Authors: Jung Eun Shim, Ji Hyun Kim, Junha Shin, Ji Eun Lee, Insuk Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007052