Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer

Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer

Abstract Introduction The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respiration. This duality of MYC underscores the importance of further invest...

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Bibliographic Details
Main Authors: Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang, Lauren A. Byers
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer & Metabolism
Subjects:
MYC
Glycolysis
Metabolism
Small cell lung cancer
PFK158
Online Access:https://doi.org/10.1186/s40170-021-00270-9

Internet

https://doi.org/10.1186/s40170-021-00270-9

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