Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT immunoglobulin. TT0170 binds fragment B, and TT00...

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Bibliographic Details
Main Authors: Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
tetanus
tetanus toxin
toxin neutralization
native human monoclonal antibody
immunoglobulin
ganglioside
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004010

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http://www.sciencedirect.com/science/article/pii/S2211124721004010

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