Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

<h4>Background</h4>Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria.<h4>Methodology/principal findings</h4>We analyzed the effect of aerobic metabolism on oxi...

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Bibliographic Details
Main Authors: Alice Zuin, Natalia Gabrielli, Isabel A Calvo, Sarela García-Santamarina, Kwang-Lae Hoe, Dong Uk Kim, Han-Oh Park, Jacqueline Hayles, José Ayté, Elena Hidalgo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18665268/?tool=EBI