Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis

Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis

Objective: Renal thrombotic microangiopathy (TMA) is associated with complement overactivation and poor outcome in patients with lupus nephritis (LN). The role of genetic makeup of complement system in these patients remains to be elucidated.Methods: The clinical and laboratory characteristics of 10...

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Bibliographic Details
Main Authors: Min-Hua Tseng, Wen-Lang Fan, Hsuan Liu, Chia-Yu Yang, Jhao-Jhuang Ding, Hwei-Jen Lee, Shih-Ming Huang, Shih-Hua Lin, Jing-Long Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
lupus nephritis
thrombotic microangiopathy
genetic background
complement factor H
complement factor I gene
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.621609/full

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https://www.frontiersin.org/articles/10.3389/fmed.2020.621609/full

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