Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice

Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice

Myeloid-derived suppressor cells (MDSC) play a crucial role in regulating the intestinal immune response during colitis. We previously revealed an essential role of MDSC in promoting TH17 cell polarization, which was found to be arginase-1 (Arg-1)-dependent; however, the underlying mechanism remains...

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Bibliographic Details
Main Authors: Zhanchuan Ma, Yu Zhen, Cong Hu, Huanfa Yi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
arginase-1
TH17 cell
IL-17A
IL-17F
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00687/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00687/full

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