Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS

Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS

Acetaminophen (APAP) is a mild analgesic and antipyretic used commonly worldwide. Although considered a safe and effective over-the-counter medication, it is also the leading cause of drug-induced acute liver failure. Its hepatotoxicity has been linked to the covalent binding of its reactive metabol...

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Bibliographic Details
Main Authors: Timon Geib, Ghazaleh Moghaddam, Aimee Supinski, Makan Golizeh, Lekha Sleno
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Chemistry
Subjects:
acetaminophen
rodent model
reactive metabolites, liver proteins
LC-MS/MS, LC-MRM
protein modification
NAPQI, N-acetyl-p-benzoquinone
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.736788/full

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https://www.frontiersin.org/articles/10.3389/fchem.2021.736788/full

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