The influence of Na+,K+-ATPase on glutamate signaling in neurodegenerative diseases and senescence

The influence of Na+,K+-ATPase on glutamate signaling in neurodegenerative diseases and senescence

Decreased Na+,K+-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β and γ, with four distinct isoforms of the catalytic α subunit (α1-4). Genetic mutations in the ATP1A2 gene and ATP1A3 gene, encodi...

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Bibliographic Details
Main Authors: Paula Fernanda Kinoshita, Jacqueline Alves Leite, Ana Maria Marques Orellana, Andrea Rodrigues Vasconcelos, Luis Eduardo M Quintas, Elisa Mitiko Kawamoto, Cristoforo eScavone
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-06-01
Series:Frontiers in Physiology
Subjects:
Aging
Neurodegenerative Diseases
Aging & Longetivity
aging neuroscience
NKA
ATP1A mutations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00195/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00195/full

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