Single-run reversed-phase HPLC method for determining sertraline content, enantiomeric purity, and related substances in drug substance and finished product

Single-run reversed-phase HPLC method for determining sertraline content, enantiomeric purity, and related substances in drug substance and finished product

A direct enantio-, diastereo-, and chemo-selective high-performance liquid chromatographic method was developed for determining the content, enantiomeric purity, and related substances of the chiral antidepressant drug sertraline HCl in a single chromatographic run. The separation was achieved on a...

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Bibliographic Details
Main Authors: Alessia Rosetti, Rosella Ferretti, Leo Zanitti, Adriano Casulli, Claudio Villani, Roberto Cirilli
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Chiralpak IG-3
Enantiomers
Diastereomers
Reversed-phase enantioselective HPLC
Sertraline HCl
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177920310777

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http://www.sciencedirect.com/science/article/pii/S2095177920310777

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