A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine

Abstract Background Several studies on gamma-irradiated influenza A virus (γ-Flu) have revealed its superior efficacy for inducing homologous and heterologous virus-specific immunity. However, many inactivated vaccines, notably in nasal delivery, require adjuvants to increase the quality and magnitu...

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Bibliographic Details
Main Authors: Ailar Sabbaghi, Masoud Malek, Sara Abdolahi, Seyed Mohammad Miri, Leila Alizadeh, Mehdi Samadi, Seyed Reza Mohebbi, Amir Ghaemi
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-021-01672-3