Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models

Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder, mostly caused by mutations in MECP2. The disorder mainly affects girls and it is associated with severe cognitive and physical disabilities. Modeling RTT in neural and glial cell cultures and brain organoids derived from patient- or mut...

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Bibliographic Details
Main Authors: Florencia D. Haase, Bronte Coorey, Lisa Riley, Laurence C. Cantrill, Patrick P. L. Tam, Wendy A. Gold
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
Rett syndrome
neurodevelopmental disorders
iPSCs (induced pluripotent stem cells)
brain organoids
disease modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.698812/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.698812/full

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