An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

Abstract Background The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideration is particularly relevant in human diseases assoc...

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Bibliographic Details
Main Authors: Janire Urrutia, Alejandra Aguado, Carolina Gomis-Perez, Arantza Muguruza-Montero, Oscar R. Ballesteros, Jiaren Zhang, Eider Nuñez, Covadonga Malo, Hee Jung Chung, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Biology
Subjects:
KCNQ channels
Epilepsy
Co-translational folding
Calmodulin
IQ domain
Encephalopathy
Online Access:https://doi.org/10.1186/s12915-021-01040-1

Internet

https://doi.org/10.1186/s12915-021-01040-1

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