Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Abstract Background Silicon dioxide nanoparticles (SiO2 NPs) are one of the most widely utilized NPs in various food sectors. However, the potential endocrine toxicity of SiO2 NPs has not been characterized. Results In the present study, mice were orally administered a series of doses of SiO2 NPs. A...

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Bibliographic Details
Main Authors: Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Particle and Fibre Toxicology
Subjects:
Silicon dioxide nanoparticles
RNA-sequencing
Endoplasmic reticulum stress
Blood glucose
Mice
Online Access:http://link.springer.com/article/10.1186/s12989-019-0327-z

Internet

http://link.springer.com/article/10.1186/s12989-019-0327-z

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