Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions

Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions

Adverse drug reactions (ADRs) remain associated with significant mortality. Delayed hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration are T-cell mediated with many severe DHRs now associated with human leukocyte antigen (HLA) risk alleles, opening pathways f...

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Bibliographic Details
Main Authors: Yueran Li, Pooja Deshpande, Rebecca J. Hertzman, Amy M. Palubinsky, Andrew Gibson, Elizabeth J. Phillips
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
delayed hypersensitivity
human leukocyte antigen
T-cell receptor
endoplasmic reticulum aminopeptidase
genetic risk
immune checkpoint
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.641905/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.641905/full

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