Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Abstract Background Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities ne...

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Bibliographic Details
Main Authors: Dan Zhou, Bonnie M. Alver, Shuang Li, Ryan A. Hlady, Joyce J. Thompson, Mark A. Schroeder, Jeong-Heon Lee, Jingxin Qiu, Philip H. Schwartz, Jann N. Sarkaria, Keith D. Robertson
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genome Biology
Subjects:
Epigenome
5mC
5hmC
5fC
5caC
Glioma stem cell
Online Access:http://link.springer.com/article/10.1186/s13059-018-1420-6

Internet

http://link.springer.com/article/10.1186/s13059-018-1420-6

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