Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome.

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome.

The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. This simulation study identifies arrhythmogenic mechanisms in the rapid-delayed rectifier K(+) current (I(Kr))-linked SQT1 v...

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Bibliographic Details
Main Authors: Ismail Adeniran, Mark J McPate, Harry J Witchel, Jules C Hancox, Henggui Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3240585?pdf=render

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