Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

Abstract Background Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted delivery of high LET radiation to the tumor microenvironment via an immune...

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Bibliographic Details
Main Authors: Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, George Sgouros
Format: Article
Language:English
Published: SpringerOpen 2017-07-01
Series:EJNMMI Research
Subjects:
Pharmacokinetics
Dosimetry
Anti-PD-L1 antibodies
Immune checkpoint inhibition
Alpha-particle emitting radioimmunotherapy
Online Access:http://link.springer.com/article/10.1186/s13550-017-0303-2

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http://link.springer.com/article/10.1186/s13550-017-0303-2

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