Copper-catalyzed methylative difunctionalization of alkenes

While the trifluoromethylative difunctionalization of unactivated alkenes has been largely explored, methylative difunctionalization remains underinvestigated. Here, the authors report copper-catalyzed alkoxy- and azido-methylation reactions of alkenes leading to important synthetic building blocks...

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Bibliographic Details
Main Authors: Xu Bao, Takayuki Yokoe, Tu M. Ha, Qian Wang, Jieping Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06246-6