The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

Pancreatic stellate cells (PSCs) are important pancreatic fibrogenic cells that interact with pancreatic cancer cells to promote the progression of pancreatic ductal adenocarcinoma (PDAC). In the tumor microenvironment (TME), several factors such as cytokines and nucleotides contribute to this inter...

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Bibliographic Details
Main Authors: Lara Magni, Rayhana Bouazzi, Hugo Heredero Olmedilla, Patricia S. S. Petersen, Marco Tozzi, Ivana Novak
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
pancreatic cancer
PDAC
pancreatic stellate cells
IL-6
Tocilizumab
P2X7R
Online Access:https://www.mdpi.com/2073-4409/10/8/1928

Internet

https://www.mdpi.com/2073-4409/10/8/1928

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