Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma...

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Bibliographic Details
Main Authors: Ke-Yu Li, Jia-Long Yuan, Diego Trafton, Jian-Xin Wang, Nan Niu, Chun-Hui Yuan, Xu-Bao Liu, Lei Zheng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-03-01
Series:Chronic Diseases and Translational Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2095882X20300025