Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

Abstract Background Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcription...

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Main Authors: Clara Lorente-Sorolla, Antonio Garcia-Gomez, Francesc Català-Moll, Víctor Toledano, Laura Ciudad, José Avendaño-Ortiz, Charbel Maroun-Eid, Alejandro Martín-Quirós, Mónica Martínez-Gallo, Adolfo Ruiz-Sanmartín, Álvaro García del Campo, Ricard Ferrer-Roca, Juan Carlos Ruiz-Rodriguez, Damiana Álvarez-Errico, Eduardo López-Collazo, Esteban Ballestar
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Medicine
Subjects:
Sepsis
DNA methylation
Cytokines
Endotoxin tolerance
Monocytes
Online Access:http://link.springer.com/article/10.1186/s13073-019-0674-2

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http://link.springer.com/article/10.1186/s13073-019-0674-2

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