Optimal ROS Signaling Is Critical for Nuclear Reprogramming

Optimal ROS Signaling Is Critical for Nuclear Reprogramming

Efficient nuclear reprogramming of somatic cells to pluripotency requires activation of innate immunity. Because innate immune activation triggers reactive oxygen species (ROS) signaling, we sought to determine whether there was a role of ROS signaling in nuclear reprogramming. We examined ROS produ...

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Bibliographic Details
Main Authors: Gang Zhou, Shu Meng, Yanhui Li, Yohannes T. Ghebre, John P. Cooke
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Subjects:
CRISPR/Cas9
iPSCs
NADPH oxidase
Nrf2
nuclear reprogramming
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303862

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http://www.sciencedirect.com/science/article/pii/S2211124716303862

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