Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents

Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents

BackgroundConcomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated with anti-TNF agents.MethodsJurkat T cells stably exp...

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Bibliographic Details
Main Authors: Qiaolei Wang, Daisuke Oryoji, Hiroki Mitoma, Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
anti-TNF agent
methotrexate
rheumatoid arthritis
transmembrane TNF
apoptosis
cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02042/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02042/full

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