Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE

Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE

Abstract Background Premature atherosclerosis occurs in patients with SLE; however, the mechanisms remain unclear. Both mitochondrial machinery and proinflammatory cytokine interferon alpha (IFN-α) potentially contribute to atherogenic processes in SLE. Here, we explore the roles of the mitochondria...

Full description

Bibliographic Details
Main Authors: Jenn-Haung Lai, Li-Feng Hung, Chuan-Yueh Huang, De-Wei Wu, Chien-Hsiang Wu, Ling-Jun Ho
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Arthritis Research & Therapy
Subjects:
CMPK2
Atherosclerosis
Interferon alpha
Macrophages
Foam cell formation
Mitochondria
Online Access:https://doi.org/10.1186/s13075-021-02470-6

Internet

https://doi.org/10.1186/s13075-021-02470-6

Similar Items