Disruption of the glutamate-glutamine cycle involving astrocytes in an animal model of depression for males and females

Background: Women are twice as likely as men to develop major depression (MD). The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-g...

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Bibliographic Details
Main Authors: Virginie Rappeneau, Amanda Blaker, Jeff R. Petro, Bryan K. Yamamoto, Akiko Shimamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Sex
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00231/full