Tests of association based on genomic windows can lead to spurious associations when using genotype panels with heterogeneous SNP densities
Abstract Dense single nucleotide polymorphism (SNP) panels are widely used for genome-wide association studies (GWAS). In these panels, SNPs within a genomic segment tend to be highly correlated. Thus, association studies based on testing the significance of single SNPs are not very effective, and g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
BMC
2021-05-01
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| Series: | Genetics Selection Evolution |
| Online Access: | https://doi.org/10.1186/s12711-021-00638-x |