Computer-Aided Approaches for Targeting HIVgp41

Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41) which advances through four distinct conformational states: (i) native, (ii) pre-hai...

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Bibliographic Details
Main Authors: William J. Allen, Robert C. Rizzo
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Biology
Subjects:
HIV
T20
Online Access:http://www.mdpi.com/2079-7737/1/2/311