Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

Green nanotechnology utilizes the principles of green chemistry to formulate eco-friendly nanocarrier systems to mitigate patients and environment hazards. Raloxifene (RLX) demonstrates poor aqueous solubility (BCS class II) and low bioavailability, only 2% (extensive first-pass metabolism). The aim...

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Bibliographic Details
Main Authors: Sara Nageeb El-Helaly, Eman Abd-Elrasheed, Samar A. Salim, Rania H. Fahmy, Salwa Salah, Manal M. EL-Ashmoony
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
green nanotechnology
raloxifene
nanoemulsion
core-sheath nanofibers
response surface methodology
ex vivo drug permeation
Online Access:https://www.mdpi.com/1999-4923/13/4/474

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https://www.mdpi.com/1999-4923/13/4/474

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