Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep.

Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep.

Prions have been documented in extra-neuronal and extra-lymphatic tissues of humans and various ruminants affected by Transmissible Spongiform Encephalopathy (TSE). The presence of prion infectivity detected in cervid and ovine blood tempted us to reason that kidney, the organ filtrating blood deriv...

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Bibliographic Details
Main Authors: Ciriaco Ligios, Giovanna Maria Cancedda, Ilan Margalith, Cinzia Santucciu, Laura Madau, Caterina Maestrale, Massimo Basagni, Mariangela Saba, Mathias Heikenwalder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1964536?pdf=render

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http://europepmc.org/articles/PMC1964536?pdf=render

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