Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expre...

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Bibliographic Details
Main Authors: Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, Andrei I. Tarasov, Quan Zhang, Eduardo Rebelato, Nils J.G. Rorsman, Rafael Martín-del-Río, Amy Lewis, Gizem Özkan, Hyun Woong Do, Peter Spégel, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Benedikt M. Kessler, Christopher W. Pugh, Jorge Tamarit-Rodriguez, Hindrik Mulder, Anne Clark, Norma Frizzell, Tomoyoshi Soga, Frances M. Ashcroft, Andrew Silver, Patrick J. Pollard, Patrik Rorsman
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
fumarate hydratase
β cell
diabetes
fumarate
glucose metabolism
hyperglycemia
insulin
mouse model
pH
succination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312354

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