Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors

Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors

Reverse transcriptase (RT) is a multifunctional enzyme in the human immunodeficiency virus (HIV)-1 life cycle and represents a primary target for drug discovery efforts against HIV-1 infection. Two classes of RT inhibitors, the nucleoside RT inhibitors (NRTIs) and the nonnucleoside transcriptase inh...

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Bibliographic Details
Main Authors: Lucianna Helene Santos, Rafaela Salgado Ferreira, Ernesto Raúl Caffarena
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-11-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
HIV-1
computer-aided drug design
reverse transcriptase inhibitors
molecular modelling
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000700847&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000700847&lng=en&tlng=en

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