Testing for direct genetic effects using a screening step in family-based association studies

In genome wide association studies (GWAS), families based studies tend to have less power to detect genetic associations than population based studies, such as case-control studies. This can be an issue when testing if genes in a family based GWAS have a direct effect on the phenotype of interest o...

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Bibliographic Details
Main Authors: Sharon M Lutz, Stijn eVansteelandt, Christoph eLange
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00243/full